Peer-reviewed veterinary case report
Toll-like receptor 2 levels linked to IBD severity in dogs
By McMahon, L A et al.·Published in Veterinary immunology and immunopathology·2010·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) showed higher levels of a specific immune marker (TLR2) in their gut tissue compared to healthy dogs. This study looked at 20 dogs with IBD and found that the increased TLR2 levels were linked to how severe their symptoms were, like diarrhea or vomiting. However, the levels of another marker (TLR4) were similar in both sick and healthy dogs. Understanding these markers could help veterinarians better assess and treat dogs with IBD, but more research is needed to see how this information can be used in practice.
People also search for: dog inflammatory bowel disease symptoms · dog IBD treatment options · why is my dog vomiting and having diarrhea
Abstract
There is growing evidence that aberrant innate immune responses towards the bacterial flora of the gut play a role in the pathogenesis of canine inflammatory bowel disease (IBD). Toll-like receptors (TLR) play an important role as primary sensors of invading pathogens and have gained significant attention in human IBD as differential expression and polymorphisms of certain TLR have been shown to occur in ulcerative colitis (UC) and Crohn's disease (CD). The aim of the current study was to evaluate the expression of two TLR important for recognition of commensals in the gut. TLR2 and TLR4 mRNA expression in duodenal biopsies from dogs with IBD was measured and correlated with clinical and histological disease severity. Endoscopic duodenal biopsies from 20 clinical cases and 7 healthy control dogs were used to extract mRNA. TLR2 and TLR4 mRNA expression was assessed using quantitative real-time PCR. TLR2 mRNA expression was significantly increased in the IBD dogs compared to controls, whereas TLR4 mRNA expression was similar in IBD and control cases. In addition, TLR2 mRNA expression was mildly correlated with clinical severity of disease, however, there was no correlation between TLR2 expression and histological severity of disease.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20034678/