Peer-reviewed veterinary case report
Protein markers in nasal carcinomas and sarcomas in dogs
By Pauly, Ljuba Anna Maria et al.·Published in Frontiers in veterinary science·2024·Department of Pathology, Germany·View original on PubMed →
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Original publication title: Expression of vascular endothelial growth factor receptor-2, epidermal growth factor receptor, cyclooxygenase-2, survivin, E-cadherin and Ki-67 in canine nasal carcinomas and sarcomas - a pilot study.
- Species:
- dog
Plain-English summary
A group of 26 dogs with nasal tumors, which often cause chronic nasal discharge, were examined to understand the types of tumors and their characteristics. The study found that 19 dogs had nasal carcinomas (a type of cancer) and 7 had nasal sarcomas (another type of tumor). Both types of tumors showed similar expressions of certain markers, suggesting that treatments like tyrosine kinase inhibitors (TKIs) or COX-2 inhibitors could be beneficial for dogs with these nasal tumors. Further research is needed to confirm the effectiveness of these treatments.
People also search for: dog nasal tumor treatment · chronic nasal discharge in dogs · nasal carcinoma in dogs · COX-2 inhibitors for dogs
Abstract
BACKGROUND: Malignant (intra-) nasal tumors (NTs) are the most common cause of chronic nasal discharge in dogs. Besides radiation therapy, palliative therapy is necessary in some dogs. Therefore, studies on receptor expression have supported the utility of tyrosine kinase inhibitors (TKI) in dogs with nasal carcinomas. However, studies on receptor expression in nasal sarcomas are lacking. MATERIALS AND METHODS: This study evaluated the expression of vascular endothelial growth factor receptor-2 (VEGFR-2), epidermal growth factor receptor (EGFR), cyclooxigenase-2 (COX-2), Ki-67, survivin and E-cadherin in nasal carcinomas and sarcomas and compared it with tumor (T) categories based on computed tomography (CT). RESULTS: In 26 dogs with NTs, cross sectional imaging and upper airway endoscopy with guided biopsy collection were performed, followed by histopathological examination of NTs, revealing 19 epithelial and 7 mesenchymal tumors. While EGFR and E-cadherin were only expressed by carcinomas, the following markers were expressed by both carcinomas and sarcomas without significant differences between tumor types and T-categories: VEGFR-2 (carcinomas and sarcomas 100%), COX-2 (carcinomas 63%, sarcomas 57%), survivin (carcinomas 100%, sarcomas 86%) and Ki-67 (median expression of 28.5% in carcinomas and 17.3% in sarcomas). CONCLUSION: Based on similarities in marker expression between canine carcinomas and sarcomas, clinical studies should further elucidate the use of TKI or COX-2 inhibitors as additional therapy in dogs with nasal sarcomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39268521/