Peer-reviewed veterinary case report
Skin protein changes in dogs with acute atopic dermatitis lesions
By Olivry, Thierry & Dunston, Stanley M·Published in Veterinary dermatology·2015·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Expression patterns of superficial epidermal adhesion molecules in an experimental dog model of acute atopic dermatitis skin lesions.
- Species:
- dog
Plain-English summary
A group of six Maltese-beagle dogs with atopic dermatitis (a skin allergy) had patches containing house dust mite allergens placed on their skin to study how their skin reacted. After 48 hours, skin samples were taken, and tests showed that certain proteins important for skin barrier function were less present in the areas exposed to the allergens compared to control patches. This suggests that the allergens can disrupt the skin's ability to protect itself, potentially allowing more allergens to penetrate the skin. Understanding these changes could help in developing better treatments for dogs with skin allergies.
People also search for: dog skin allergy treatment · Maltese-beagle atopic dermatitis · house dust mite allergy in dogs
Abstract
BACKGROUND: The stratum corneum is critical for providing a functional skin barrier, especially in humans and dogs with atopic dermatitis. An effective barrier also depends upon intact corneodesmosomes and superficial epidermal tight junctions. HYPOTHESIS/OBJECTIVES: To study the expression of selected corneodesmosome, desmosome, tight and adherens junction proteins in an experimental model of acute atopic dermatitis skin lesions in dogs. METHODS: Control and house dust mite (HDM) allergen-containing patches (two types of patches) were applied to the skin of six Maltese-beagle atopic dogs hypersensitive to HDM. Patches were left on for 48 h, and biopsies were collected 24 h after removal. Frozen skin sections were stained by indirect immunofluorescence for corneodesmosin, desmoglein-1, desmocollin-1, claudin-1 and E-cadherin. Immunostains were assessed for their extent, intensity and patterns; they were compared between HDM and control patches on the same dogs. RESULTS: The immunostaining for E-cadherin, desmocollin-1 and desmoglein-1 was homogeneous, intercellular and continuous in all control and HDM patches. The immunoreactivity of corneodesmosin and claudin-1 was heterogeneous and reduced in intensity in 12 of 12 and eight of 12 HDM patches, respectively, in contrast to a normal expression seen in all control samples (Fisher's test, P < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: These observations suggest that HDM allergens, via proteolytic digestion and/or because of induced allergic inflammation, affect the expression and possible function of corneodesmosomal and tight junction proteins. Ensuing intercellular junction alterations might promote an abnormally increased penetration of allergens through the epidermis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25496350/