Peer-reviewed veterinary case report
Cytokine levels in joint tissues of dogs with osteoarthritis
By Maccoux, Lindsey J et al.·Published in Veterinary immunology and immunopathology·2007·University of Manchester, United Kingdom·View original on PubMed →
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Original publication title: Expression profiling of select cytokines in canine osteoarthritis tissues.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis (OA), often caused by issues like torn ligaments or hip dysplasia, had their joint tissues examined to understand inflammation better. Researchers found that certain proteins linked to inflammation, called cytokines, were present in higher amounts in the joints of dogs with OA compared to healthy dogs. Specifically, increased levels of interleukin-1beta and interleukin-6 were noted in the affected tissues. This information could help veterinarians develop better treatments for dogs suffering from joint pain and inflammation due to OA.
People also search for: dog osteoarthritis treatment · symptoms of dog joint pain · what is interleukin in dogs
Abstract
The objective of this study was to investigate the level of expression of five cytokines in four different articular tissues from the joints of dogs with and without osteoarthritis (OA). Articular tissues were harvested from the stifle (fat, cranial cruciate ligament, synovial membrane) or hip (articular cartilage) from eight dogs with OA secondary to cranial cruciate ligament disease (stifle) or hip dysplasia (hip), undergoing routine surgical treatment for the condition, and from five dogs euthanatized without orthopaedic disease. The mRNA transcript numbers for interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and interleukin-17 (IL-17) were determined by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR). Increased expression of IL-1beta, IL-6 and IL-10 in OA synovial membrane, increased expression of IL-1beta and IL-6 in ruptured (OA) ligament, and reduced expression of IL-8 in OA synovial membrane were identified. Cytokine expression was detected in multiple tissues within the articular joint, but differential expression in OA was detected primarily in the synovial membrane and cranial cruciate ligament.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17524496/