Peer-reviewed veterinary case report
Dog with skin tumors linked to duodenal cancer metastasis
By Juopperi, Tarja A et al.·Published in Veterinary clinical pathology·2003·Department of Microbiology, United States·View original on PubMed →
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Original publication title: Extensive cutaneous metastases in a dog with duodenal adenocarcinoma.
- Species:
- dog
Plain-English summary
A 6-year-old Rottweiler was brought to the vet because he had multiple lumps on his skin, along with a history of not eating, vomiting, and weakness in his back legs. Tests showed that these skin nodules were actually cancerous growths spreading from a primary tumor in his intestines. Unfortunately, the cancer had spread extensively, affecting not just the skin but also other organs. The dog was diagnosed with duodenal adenocarcinoma, a type of intestinal cancer, and the prognosis was poor due to the widespread nature of the disease.
People also search for: dog skin lumps cancer · Rottweiler vomiting and weakness · dog intestinal cancer treatment
Abstract
A 6-year-old Rottweiler was presented to the North Carolina State University College of Veterinary Medicine for evaluation of multiple cutaneous nodules. The dog had a history of anorexia, vomiting, and hind-limb paraplegia. Results of cytologic examination of the cutaneous nodules were consistent with a round cell tumor. At necropsy, primary tumors were found coalescing in the duodenum and the pancreas and extending into the associated mesentery. Numerous masses also were found throughout the skin, abdominal and thoracic viscera, and lumbar spinal cord. Histologically, the duodenal tumor had variable morphology, with some areas resembling adenocarcinoma and others resembling anaplastic round cell neoplasia; the skin and other metastatic lesions resembled round cell neoplasia. Immunohistochemistry of the cutaneous, duodenal, and pancreatic masses showed the neoplastic cells were positive for pancytokeratin, supporting an epithelial origin. In addition, low numbers of neoplastic cells were positive for periodic acid-Schiff and Alcian blue, consistent with acid mucin production by duodenal epithelium. These findings confirmed that the cutaneous nodules were metastatic lesions originating from the duodenal adenocarcinoma. Cutaneous metastasis of intestinal carcinoma is rare in domestic animals. This case demonstrates the potential difficulty in diagnosing metastatic lesions based on cytologic and histologic morphology alone, because the cutaneous metastases may not resemble the primary neoplasm morphologically.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12833224/