Extra-gastrointestinal stromal tumor of the prostate — a case report and literature review

Abstract

Extra-gastrointestinal stromal tumors (EGISTs) primarily originate outside the gastrointestinal tract and are not associated with the walls of the stomach or intestines. They typically arise from the omentum, mesentery, peri­toneum, retroperitoneum, and genitourinary regions. However, EGISTs originating from the prostate are exceed­ingly rare. Herein, a case is presented of an EGIST arising from prostatic tissue. The patient underwent radical prostatectomy. Histopathological examination revealed spindle-shaped tumor cells. Immunohistochemical analysis demonstrated positive expression of CD117, DOG-1, and CD34, leading to the diagnosis of a gas­trointestinal stromal tumor (GIST). Radiologic staging showed no evidence of residual disease or metastasis; however, due to the high-risk nature of the tumor, adjuvant imatinib therapy was initiated. No recurrence or metastasis was observed during a one-year follow-up period, and the patient continues to be monitored reg­ularly. This article also provides a comprehensive review of the clinical characteristics, histopathology, and treatment of EGIST cases reported in the literature.