Peer-reviewed veterinary case report
Heat shock protein 70 found in spinal fluid of dogs with Steroid
By Moore, Sarah A et al.·Published in Veterinary immunology and immunopathology·2012·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Extracellular hsp70 release in canine Steroid Responsive Meningitis-Arteritis.
- Species:
- dog
Plain-English summary
A group of dogs with Steroid Responsive Meningitis-Arteritis (SRMA), a condition that causes inflammation in the brain and spinal cord, showed increased levels of a protein called heat shock protein 70 (ehsp70) in their cerebrospinal fluid. This protein is linked to inflammation and was found to decrease when the dogs were treated with corticosteroids, a common anti-inflammatory medication. The study suggests that measuring ehsp70 could help understand how inflammation works in dogs with SRMA. With proper treatment, many dogs with this condition can achieve remission and feel better.
People also search for: dog meningitis treatment · SRMA in dogs symptoms · corticosteroids for dog inflammation
Abstract
The role of extracellular 70 kDa heat shock protein 70 (ehsp70) in central nervous system inflammation is vastly understudied, despite evidence supporting the ability to drive a pro-inflammatory state. We investigated the presence of ehsp70 in cerebrospinal fluid (CSF) and serum of dogs with Steroid Responsive Meningitis-Arteritis (SRMA), with the hypothesis that an ehsp70 response would occur, and might play a role in the pathogenesis of this disease. Samples from 30 dogs acutely affected with SRMA, and 30 dogs treated with corticosteroids and currently in clinical remission from SRMA were compared with normal dogs. Serum and CSF concentrations of ehsp70 were quantified using an enzyme-linked immunosorbent assay. An ehsp70 response occurred in the CSF of dogs with SRMA and this response was attenuated by corticosteroid treatment. There was no correlation between serum and CSF concentrations of ehsp70, supporting local production and release of ehsp70 and not simply leakage from serum. Dogs with SRMA thus represent a powerful spontaneous model by which to study the role of ehsp70 in CNS inflammation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22100193/