Peer-reviewed veterinary case report
Bleeding problems from factor XI deficiency in Kerry Blue Terriers
By Knowler, C et al.·Published in Journal of the American Veterinary Medical Association·1994·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Factor XI deficiency in Kerry Blue Terriers.
- Species:
- dog
Plain-English summary
A 9-year-old female Kerry Blue Terrier experienced excessive bleeding after surgery, leading to tests that revealed she had factor XI deficiency, a condition affecting blood clotting. To manage the bleeding, she received fresh-frozen plasma transfusions for four days, which helped stabilize her clotting times and control the hemorrhage. Other Kerry Blue Terriers with the same deficiency also showed a tendency for mild bleeding after injuries or surgeries, suggesting this condition may be inherited. With the right treatment, this dog was able to recover from her bleeding issues.
People also search for: Kerry Blue Terrier bleeding after surgery · factor XI deficiency in dogs · dog blood clotting problems treatment
Abstract
A 9-year-old female Kerry Blue Terrier with postoperative hemorrhage and prolonged activated partial thromboplastin and activated clotting times was determined to have factor XI deficiency. Transfusions of fresh-frozen plasma given on 4 consecutive days transiently returned the values for activated clotting time and plasma factor XI activity to within reference range limits and controlled the hemorrhage. Analysis of data from 10 other factor XI-deficient Kerry Blue Terriers with a tendency for mild posttraumatic or postoperative bleeding was suggestive of an autosomal mode of inheritance, with a mild tendency for posttraumatic or postoperative bleeding in homozygous and heterozygous dogs. Factor XI deficiency is the only contact phase protein defect that causes a bleeding disorder in animals, which can be explained by the fact that thrombin is more efficient than factor XIIa in activating factor XI. Factor XIa plays a key role in sustaining coagulation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7730123/