Peer-reviewed veterinary case report
Parvovirus DNA found in cat poop after feline panleukopenia vaccine
By Bergmann, Michèle et al.·Published in The Veterinary record·2019·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Faecal shedding of parvovirus deoxyribonucleic acid following modified live feline panleucopenia virus vaccination in healthy cats.
- Species:
- cat
Plain-English summary
A group of 40 healthy adult cats were vaccinated with a modified live vaccine for feline panleukopenia and then tested for parvovirus DNA in their feces over the following month. About 30% of the cats shed parvovirus DNA, with some shedding the vaccine strain and others shedding wild strains of the virus. The study found that cats with lower antibody levels before vaccination were more likely to shed the virus after getting vaccinated. This shedding could be a concern in places like shelters, where it might spread to other cats.
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Abstract
Positive canine parvovirus (CPV) faecal test results have been reported in dogs after modified live virus (MLV) vaccination. Thus, the aim was to investigate feline panleucopenia virus (FPV) shedding in recently vaccinated, adult, clinically healthy cats and to assess related factors. Forty cats were vaccinated with an FPV MLV vaccine. Faeces of cats were tested for presence of parvovirus DNA on days 7, 14, 21 and 28 by quantitative real-time PCR; DNA-positive samples were subjected to partial VP2 gene sequencing. Virus isolation was performed whenever sufficient amounts of faeces were available. Serum antibody titres were measured by haemagglutination inhibition on days 0, 7 and 28. Overall, 30.0 per cent (12/40; 95% CI 18.0 to 45.6) of cats shed parvovirus DNA. Sequencing revealed FPV vaccine virus DNA in three cats, FPV field virus DNA in four cats and CPV field virus DNA in one cat. Shedding was significantly associated with lack of prevaccination antibody titres (40) (P=0.016; OR: 6.44; 95% CI 1.44 to 28.89) and with postvaccination titre increases (fourfold) (P=0.029; OR: 5.00; 95% CI 1.17 to 21.39). Shedding of field or vaccine virus DNA seems to be common in healthy cats which can be a concern in shelters and catteries. Diagnostic tools should be developed to facilitate differentiation of vaccine and field virus shedding.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31040216/