Peer-reviewed veterinary case report
Kidney disease causing protein in urine in adult Beagles from one
By Rha, J Y et al.·Published in Journal of the American Veterinary Medical Association·2000·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Familial glomerulonephropathy in a litter of beagles.
- Species:
- dog
Plain-English summary
Five adult Beagles from the same litter were found to have a kidney disease called membranoproliferative glomerulonephropathy. At 8 years old, two of the dogs showed symptoms like increased thirst and urination, along with occasional vomiting and loss of appetite. Tests revealed they had kidney issues, including protein in their urine. A biopsy confirmed the diagnosis, showing thickened kidney structures. This suggests a genetic link to the disease, and further research is needed to understand how it may be inherited in Beagles.
People also search for: Beagle kidney disease symptoms · dog vomiting and increased thirst · hereditary kidney problems in Beagles
Abstract
Membranoproliferative glomerulonephropathy was diagnosed in 5 of 7 adult Beagles from the same litter. Dogs were raised in more than 1 area of the United States. One died without evidence of renal disease when it was 3 years old. At 8 years of age, 2 dogs developed signs of uremia, including polyuria, polydipsia, and infrequent episodes of anorexia and vomiting. Serum biochemical variables and urine specific gravity values were consistent with renal azotemia. Both dogs had proteinuria. Although healthy, 3 of the 4 remaining Beagles had proteinuria. Of these 3, only 1 was azotemic. Membranoproliferative glomerulonephritis was diagnosed on the basis of results of histologic examination of renal biopsy specimens from 4 of the dogs. Electron microscopy performed on 3 of the renal biopsy specimens revealed identical lesions, consisting of an extremely thickened glomerular basement membrane with multilaminar splitting. Immunoglobulin or amyloid deposits were not detected. On the basis of similar clinicopathologic abnormalities, common genetic background, and identical histopathologic and electron microscopic findings, familial renal disease was diagnosed. Additional studies involving other related Beagles are needed to identify the hereditary nature of membranoproliferative glomerulonephropathy in Beagles.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10638317/