Peer-reviewed veterinary case report
Dog with adrenal tumor, Cushing's, and diabetes treated successfully
By Ga-Won Lee et al.·Published in BMC Veterinary Research·2020·Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, GB·View original on DOAJ →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Favorable outcome of pheochromocytoma in a dog with atypical Cushing’s syndrome and diabetes mellitus following medical treatment: a case report
- Species:
- dog
Plain-English summary
A 14-year-old male Poodle was brought in with an abdominal mass and symptoms like high blood pressure, cloudy eyes, and hair loss. Tests revealed he had a pheochromocytoma (a type of tumor on the adrenal gland), atypical Cushing’s syndrome, and diabetes. The dog was treated with medications including trilostane, phenoxybenzamine, and insulin, which helped lower his blood sugar and blood pressure. After 10 months, his liver enzymes improved, and he showed no worsening of symptoms, indicating that the treatment was effective in managing his condition without needing surgery.
People also search for: dog abdominal mass treatment · Poodle high blood pressure · pheochromocytoma in dogs · atypical Cushing's syndrome management · diabetes in dogs treatment
Abstract
Abstract Background Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs. Case presentation A 14-year-old castrated male Poodle dog presented with an abdominal mass. On physical examination, hypertension, increased lens opacity, calcinosis cutis, generalized alopecia, and systolic murmur were observed. Serum chemistry and urinalysis profiles revealed hyperglycemia, hypercholesterolemia, elevated liver enzymes, and glucosuria. Abdominal ultrasonography showed a right adrenal mass with invasion of the caudal vena cava, which was cytologically diagnosed as suspected PCC. An adrenal mass (width × height × length, 28 × 26 × 48 mm3) was found on computed tomography and diagnosed as PCC with increased plasma metanephrines and normetanephrines. An adrenocorticotropin hormone stimulation test showed elevated adrenal hormones (androstenedione, estradiol, progesterone, and 17-OH progesterone) with normal cortisol, compatible with atypical Cushing’s syndrome. The dog was managed with trilostane, phenoxybenzamine, and insulin therapy. Glycosylated hemoglobin and fructosamine levels gradually decreased, and hypertension resolved. In the 10-month follow-up period, the liver enzymes levels gradually decreased, and the clinical signs of the dog were well-controlled without deterioration. Conclusions This case report describes long-term medical management without adrenalectomy of PCC complicated with atypical Cushing’s syndrome and DM.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on DOAJ: https://doi.org/10.1186/s12917-019-2225-x