Peer-reviewed veterinary case report
Detecting liver metastases in dogs using gadobenate dimeglumine MRI
By Louvet, Arnaud & Duconseille, Anne-Carole·Published in Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2015·Centre d'Imagerie par Ré, France·View original on PubMed →
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Original publication title: Feasibility for detecting liver metastases in dogs using gadobenate dimeglumine-enhanced magnetic resonance imaging.
- Species:
- dog
Plain-English summary
A group of dogs with known primary tumors underwent special MRI scans using a contrast agent called gadobenate dimeglumine to check for liver metastases (cancer spread to the liver). The scans showed that this method was effective in finding more liver lesions compared to standard imaging techniques. In fact, the best results were seen when the scans were done less than 30 minutes after the contrast was injected. This study suggests that using gadobenate dimeglumine-enhanced MRI could help veterinarians detect liver metastases earlier, potentially improving treatment outcomes for affected dogs.
People also search for: dog liver cancer symptoms · MRI for dog liver metastases · gadobenate dimeglumine for dogs
Abstract
Early detection of liver metastases may improve the prognosis for successful treatment in dogs with primary tumors. Hepatobiliary-specific contrast agents have been shown to allow an increase in magnetic resonance imaging (MRI) detection of liver metastases in humans. The purpose of this prospective study was to test the feasibility for using one of these agents, gadobenate dimeglumine, to detect liver metastases in dogs. Ten consecutive dogs known to have a primary tumor were recruited for inclusion in the study. All dogs were scanned using the same protocol that included a T2-weighted respiratory-triggered sequence, T1 VIBE, diffusion-weighted imaging, and 3D-FLASH before and after dynamic injection of gadobenate dimeglumine contrast medium. Delayed imaging was performed less than 30 min after injection and up to 60 min in two cases. Histological analysis of liver lesions identified in delayed phases was performed for each case and confirmed metastatic origin. In all cases, lesion number detected in hepatobiliary contrast-enhanced sequences was statistically higher than in other sequences. Optimal lesion detection occurred with a 3D-FLASH sequence acquired in the transverse plane and less than 30 min after injection. Findings indicated that gabobenate dimeglumine enhanced MRI is a feasible technique for detecting liver metastases in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25529873/