Peer-reviewed veterinary case report
Steroid treatment for esophageal ulcers after EMR in dogs
By Honda, Michitaka et al.·Published in Journal of gastroenterology·2011·Department of Bioartificial Organs, Japan·View original on PubMed →
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Original publication title: Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model.
- Species:
- dog
Plain-English summary
A group of nine beagle dogs underwent a procedure to remove ulcers from their esophagus, and researchers tested different steroid treatments to see how they affected healing. One group received steroid injections directly into the ulcer site, while another group took steroids orally, and a control group received no treatment. The results showed that the injected steroids actually worsened the ulcers and delayed healing, while the oral steroids did not significantly improve the healing process either. Overall, the study suggests that while steroids are commonly used, they may not be beneficial for this type of injury in dogs.
People also search for: dog esophageal ulcer treatment · beagle esophagus healing · steroid side effects in dogs
Abstract
BACKGROUND: Intralesional or systemic steroid administration is a promising strategy for the prevention of esophageal stricture after endoscopic therapy. The aim of this study was to evaluate the influence of steroid therapy on the process of healing of defects in the esophageal mucosa after endoscopic mucosal resection (EMR). METHODS: Nine beagle dogs were divided into three equal groups: group A, intralesional injection (n = 3), group B, peroral administration (n = 3), and group C, untreated control (n = 3). In group A, triamcinolone acetonide 1 ml (10 mg) was injected directly into the exposed submucosal layer immediately after EMR, and again on postoperative day (POD) 7. In group B, dogs were administered prednisolone 0.5 mg/kg/day orally for 14 days after EMR. In group C, 1 ml normal saline was injected by the same method as that used for group A. On POD 28, histological examination was performed to evaluate epithelialization, inflammation, angiogenesis, and atrophy of the muscularis propria. RESULTS: In groups A, B, and C, the mean ulcer area was 50.1, 22.7, and 7.4 mm(2), respectively. The difference between groups A and C was significant (p < 0.01). Inflammatory cells were significantly more evident in the lesions of group A than in those of group C (p < 0.05). In all groups, atrophy of the muscularis propria was evident. However, transmural destruction and fibrosis were observed only in group A. CONCLUSION: It was speculated that the esophageal ulcer causes the fibrosis of the submucosa and atrophy of the muscularis propria during process of healing. Intralesional steroid injection deepened the esophageal ulcers and delayed epithelialization, whereas systemic administration did not clearly improve the lesion healing process.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21597933/