Peer-reviewed veterinary case report
Fecal microbiome changes in dachshunds with colorectal polyps
By Igarashi, Hirotaka et al.·Published in Research in veterinary science·2016·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Fecal dysbiosis in miniature dachshunds with inflammatory colorectal polyps.
Plain-English summary
A group of miniature dachshunds with chronic gastrointestinal issues were found to have inflammatory colorectal polyps, which are growths in the colon that can cause discomfort. Researchers discovered that the gut bacteria in these affected dogs were significantly different from those in healthy dachshunds, with certain harmful bacteria being more abundant. This suggests that the imbalance in gut bacteria might be linked to the polyps and could be a target for future treatments. More studies are needed to explore how to best address this issue in affected dogs.
People also search for: miniature dachshund gastrointestinal problems · dog inflammatory colorectal polyps · gut bacteria imbalance in dogs
Abstract
Chronic gastrointestinal disease is associated with the alteration of gastrointestinal microbiota. Inflammatory colorectal polyps (ICRPs) are commonly observed in miniature dachshunds (MDs) in Japan and are characterized by multiple polyps that are restricted in the colorectal mucosa with severe neutrophil infiltration. This study was aimed to compare the fecal microbiota of ICRP-affected MDs with that of healthy MDs. High-throughput sequencing of amplicons derived from the V3-V4 region of the 16S rRNA gene was applied using the Illumina MiSeq system. Principal coordinates analysis revealed that fecal microbiota of ICRP-affected MDs was significantly altered compared with that of healthy MDs. Proportions of Fusobacteriaceae, Helicobacteraceae, Porphyromonadaceae, and Turicibacteraceae were significantly more abundant in ICRP-affected MDs, while those of Lachnospiraceae were significantly less abundant in ICRP-affected MDs compared with healthy MDs. These results suggest that the dysbiosis is associated with ICRPs and is a potential therapeutic target, though further investigations are needed.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27033906/