Peer-reviewed veterinary case report
Fecal dysbiosis in miniature dachshunds with inflammatory colorectal polyps.
- Journal:
- Research in veterinary science
- Year:
- 2016
- Authors:
- Igarashi, Hirotaka et al.
- Affiliation:
- Department of Veterinary Internal Medicine · Japan
Plain-English summary
This study looked at miniature dachshunds in Japan that have inflammatory colorectal polyps, which are growths in the colon that can cause gastrointestinal issues. The researchers compared the gut bacteria of these affected dogs to healthy miniature dachshunds and found that the gut bacteria were significantly different. Certain types of bacteria were much more common in the dogs with polyps, while others were less so. This change in gut bacteria, known as dysbiosis, might be linked to the polyps and could be something to target for treatment, but more research is needed to confirm this.
Abstract
Chronic gastrointestinal disease is associated with the alteration of gastrointestinal microbiota. Inflammatory colorectal polyps (ICRPs) are commonly observed in miniature dachshunds (MDs) in Japan and are characterized by multiple polyps that are restricted in the colorectal mucosa with severe neutrophil infiltration. This study was aimed to compare the fecal microbiota of ICRP-affected MDs with that of healthy MDs. High-throughput sequencing of amplicons derived from the V3-V4 region of the 16S rRNA gene was applied using the Illumina MiSeq system. Principal coordinates analysis revealed that fecal microbiota of ICRP-affected MDs was significantly altered compared with that of healthy MDs. Proportions of Fusobacteriaceae, Helicobacteraceae, Porphyromonadaceae, and Turicibacteraceae were significantly more abundant in ICRP-affected MDs, while those of Lachnospiraceae were significantly less abundant in ICRP-affected MDs compared with healthy MDs. These results suggest that the dysbiosis is associated with ICRPs and is a potential therapeutic target, though further investigations are needed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27033906/