Peer-reviewed veterinary case report
Fecal transplant helped a ferret with chronic diarrhea and digestion
By Ravel SJ & Hollifield VM·Published in Veterinary Medicine: Research and Reports·2024
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Original publication title: Fecal Microbiota Transplantation in a Domestic Ferret Suffering from Chronic Diarrhea and Maldigestion–Fecal Microbiota and Clinical Outcome: A Case Report
- Species:
- rodent
Plain-English summary
A 4-year-old spayed female ferret was brought in for chronic diarrhea, weight loss, and maldigestion. The vet tried fecal microbiota transplantation (FMT) to help restore her gut health, starting with oral treatments that showed some temporary improvement. However, the best results came from administering FMT via enema, which helped normalize her gut bacteria over time. While her symptoms improved initially, they returned, suggesting that she might need repeated treatments for lasting relief.
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Abstract
Sean J Ravel, Victoria M Hollifield Best Friends’ Veterinary Hospital, Gaithersburg, MD, USACorrespondence: Sean J Ravel, Email sean.ravel01@gmail.comAbstract: This case report describes the effects of fecal microbiota transplantation (FMT) administered via enema in a 4-year-old spayed, champagne Domestic Ferret (Mustela putorius furo) with chronic diarrhea, maldigestion and weight loss. We aimed to establish a protocol for FMT as a novel therapeutic treatment for chronic diarrhea in domestic ferrets. We mapped the fecal microbiome by 16S rRNA gene amplicon sequencing to track the patient’s fecal microbiota throughout the treatment and observation period. Initial oral FMTs were associated with temporary weight improvement but subsequent treatments, via enema and oral delivery, showed varied outcomes. Molecular analysis highlighted distinct gut microbiota composition profiles between the healthy donor and the diseased ferret. The diseased ferret initially exhibited high abundance of Enterobacteriaceae, Escherichia, and Enterobacter, which ultimately normalized to level like those found in the donor ferret. Overall, the gut microbiota of the recipient became more similar to the donor microbiota using a Yue-Clayton theta coefficients analysis. After a restoration of the gut microbiota and clinical improvement, the recipient’s symptoms returned indicating that repeated FMTs might be required for long-term resolution of symptoms and complete restructuring of the gut microbiota. Future studies are warranted to map the microbiome of a larger population of domestic ferrets to investigate a potential correlation between fecal microbiota profiles and chronic/acute gastrointestinal disorders.Keywords: fecal microbiota transplant, FMT, gut microbiome, exotic pets, microbiota restoration
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