Peer-reviewed veterinary case report
Fecal transplant to help puppies recover from parvovirus diarrhea
By Pereira, Giorgio Q et al.·Published in Journal of veterinary internal medicine·2018·Department of Clinical Studies, Brazil·View original on PubMed →
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Original publication title: Fecal microbiota transplantation in puppies with canine parvovirus infection.
- Species:
- dog
Plain-English summary
Sixty-six puppies with parvovirus infection, which caused severe diarrhea, were treated at two veterinary hospitals. Half of the puppies received standard treatment with IV fluids and antibiotics, while the other half also received a fecal microbiota transplant (FMT) from a healthy dog. The puppies that received FMT had diarrhea resolve more quickly and spent less time in the hospital compared to those who only received standard treatment. While the mortality rate was lower in the FMT group, the difference wasn't significant. Overall, FMT showed promise in helping puppies recover from parvovirus infection faster.
People also search for: puppy parvovirus treatment · fecal transplant for dogs · diarrhea in puppies · parvovirus recovery time
Abstract
BACKGROUND: Diarrhea associated with parvovirus infection is common in dogs. Supportive care is the mainstay of treatment, but recovery may be prolonged and mortality rate can be high. Modification of the intestinal bacterial microbiota has been promising in human and veterinary medicine as an adjunctive treatment of various enteric diseases. OBJECTIVES: To investigate the safety and efficacy of fecal microbiota transplantation (FMT) on the clinical recovery of puppies with acute hemorrhagic diarrhea syndrome. ANIMALS: Sixty-six puppies with parvovirus infection were evaluated at 2 veterinary hospitals. METHODS: Randomized clinical trial. Puppies were randomly distributed into 2 groups: standard treatment (STD) and standard treatment + FMT (STD + FMT). The STD puppies (n = 33) received only treatment with IV fluids and antimicrobials and the STD + FMT puppies (n = 33) received FMT in addition to standard treatment. For FMT, 10 g of feces from a healthy dog diluted in 10 mL of saline were administered rectally 6-12 hours post-admission. RESULTS: Among survivors, treatment with FMT was associated with faster resolution of diarrhea (P < .001) and shorter hospitalization time (P = .001; median, 3 days in STD + FMT; median, 6 days in STD) compared to standard treatment. Mortality in STD was 36.4% (12/33) as compared to 21.2% (7/33) in puppies treated with FMT, but there was no statistical difference between groups (P = .174). Polymerase chain reaction indicated that all animals carried canine parvovirus, strain CPV-2b. CONCLUSIONS: Fecal microbiota transplantation in parvovirus-infected puppies was associated with faster resolution of diarrhea.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29460302/