Peer-reviewed veterinary case report
Feline coronavirus antibody levels in spinal fluid of cats
By Soma, Takehisa et al.·Published in The Journal of veterinary medical science·2018·Veterinary Diagnostic Laboratory, Japan·View original on PubMed →
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Original publication title: Feline coronavirus antibody titer in cerebrospinal fluid from cats with neurological signs.
- Species:
- cat
Plain-English summary
A group of cats showing neurological signs, suspected of having feline infectious peritonitis (FIP), were tested for antibodies against feline coronavirus in their cerebrospinal fluid (CSF). Out of 271 cats, 28 had detectable antibodies, with 13 showing high levels that suggested a strong link to FIP. In these cases, the tests also revealed the presence of the virus's genetic material in the CSF. This indicates that a high antibody titer in the CSF could help veterinarians diagnose FIP more accurately.
People also search for: cat neurological signs · feline infectious peritonitis diagnosis · cat coronavirus treatment
Abstract
To investigate the utility of cerebrospinal fluid (CSF) anti-feline coronavirus (FCoV) antibody test for diagnosis of feline infectious peritonitis (FIP), the antibody titers were tested in CSF and sera from 271 FIP-suspected neurological cats. CSF antibody was detected in 28 cats, which were divided into 2 groups; 15 with CSF titer of 1:80 or lower and 13 with CSF titer of 1:640 or higher. In the latter group, reciprocal serum titer/reciprocal CSF titer was 8 or lower, which is extremely lower than normal range (256-2048), and FCoV RNA was detected in all of 11 CSF samples assayed by RT-PCR. Our findings indicate that CSF titer of 1:640 or higher may be served as a candidate for the index for diagnosing FIP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29118313/