Peer-reviewed veterinary case report
Cat with nasal infection linked to feline infectious peritonitis virus
By André, Nicole M et al.·Published in Journal of Feline Medicine and Surgery Open Reports·2020·Departments of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA, United States·View original on Crossref →
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Original publication title: Feline infectious peritonitis virus-associated rhinitis in a cat
- Species:
- cat
Plain-English summary
A cat adopted from a shelter developed breathing problems and later showed signs of severe feline infectious peritonitis (FIP), a serious viral disease. Tests revealed inflammation in the nasal cavity and other organs, confirming the presence of the FIP virus. This case highlights how respiratory issues can be part of the disease's progression. Unfortunately, FIP is often fatal, and treatment options are limited, but early detection and supportive care can help manage symptoms.
People also search for: cat breathing problems · feline infectious peritonitis symptoms · FIP treatment options · cat respiratory infection causes
Abstract
Case summary This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine and small intestine. Histologic examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with monoclonal antibody FIPV3-70 targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of an FIP virus. Pathological changes, immunolabeling and molecular analysis provide evidence that respiratory infection by feline coronavirus is part of the spectrum of FIP-associated disease. Relevance and novel information This report highlights nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry and molecular characterization of the virus. Our work supports a little-appreciated role of the respiratory tract in FIP.
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Search related cases →Original publication on Crossref: https://doi.org/10.1177/2055116920930582