Peer-reviewed veterinary case report
Cat with severe mouth inflammation linked to abnormal proteins
By Lyon, K F·Published in Journal of veterinary dentistry·1994·Department of Dentistry·View original on PubMed →
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Original publication title: Feline lymphoplasmacytic stomatitis associated with monoclonal gammopathy and Bence-Jones proteinuria.
- Species:
- cat
Plain-English summary
An 8-year-old female domestic shorthair cat was brought in with severe inflammation in her mouth, causing painful stomatitis and gingivitis. Tests showed she had a condition called monoclonal gammopathy, which is linked to abnormal protein production in her blood. To treat her, the veterinarian used chemotherapy with alkylating agents, which helped reduce the harmful proteins. After treatment, the cat's symptoms improved, and she was more comfortable.
People also search for: cat mouth inflammation treatment · feline stomatitis causes · cat chemotherapy for multiple myeloma
Abstract
Lymphoplasmacytic stomatitis and gingivitis was diagnosed in an 8-year old female domestic shorthair. The cat had evidence of severe generalized inflammation of the oral cavity. Biopsy samples were evaluated and displayed a lichenoid, interface stomatitis which was predominantly lymphoplasmacytic. Serum protein electrophoresis confirmed a monoclonal gammopathy. Urine protein electrophoresis confirmed Bence-Jones proteinuria. Protein electrophoresis was used to diagnose monoclonal gammopathy (the production of a monoclonal immunoglobulin, or paraprotein, which is associated with a characteristic "M" protein spike on serum electrophoresis). Diseases associated with monoclonal gammopathy are similar in the dog and cat. Alkylating agent chemotherapy is used to rapidly reduce paraprotein concentrations in multiple myeloma. Multiple myeloma is the most common disorder associated with monoclonal gammopathy. This condition is less common in the cat, compared to the dog. This report examines the diagnosis and treatment of multiple myeloma in a cat presenting with severe stomatitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7993584/