Peer-reviewed veterinary case report
Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2013
- Authors:
- Pang, L Y et al.
- Affiliation:
- The Roslin Institute and Royal (Dick) School of Veterinary Studies · United Kingdom
- Species:
- cat
Abstract
Cancer stem cells were identified in a feline mammary carcinoma cell line by demonstrating expression of CD133 and utilising the tumour sphere assay. A population of cells was identified that had an invasive, mesenchymal phenotype, expressed markers of pluripotency and enhanced tumour formation in the NOD-SCID mouse and chick embryo models. This population of feline mammary carcinoma stem cells was resistant to chemotherapy and radiation, possibly due to aberrant activation of the ATM/p53 DNA damage pathway. Epithelial-mesenchymal transition was a feature of the invasive phenotype. These data demonstrate that cancer stem cells are a feature of mammary cancer in cats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23219486/