Peer-reviewed veterinary case report
How obesity affects blood and health in cats
By Martins, Tainara de Oliveira et al.Ā·Published in Veterinary research communicationsĀ·2023Ā·Roque Quagliato Veterinary Hospital, BrazilĀ·View original on PubMed ā
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Original publication title: Feline obesity causes hematological and biochemical changes and oxidative stress - a pilot study.
- Species:
- cat
Plain-English summary
A study found that obesity in cats can lead to changes in blood and stress levels that may affect their health. In this research, 45 cats were divided into three groups: normal weight, overweight, and obese. The obese cats showed higher levels of certain blood components and increased oxidative stress, which can cause cellular damage over time. These findings suggest that being overweight or obese can negatively impact a cat's overall health. If your cat is overweight, it might be a good idea to discuss weight management strategies with your veterinarian.
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Abstract
Obesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n = 17), overweight (n = 13) and obese (n = 15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. Obese cats showed increased mean corpuscular volume (MCV), red cell distribution width (RDW), HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT) than control cats, although within the reference ranges for the species. As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2'-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS + HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS + HRP and TAC-FRAP than control cats. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35778642/