Peer-reviewed veterinary case report
Bone growths causing joint stiffness in a 12-year-old cat
By Gómez, Álex et al.·Published in Journal of comparative pathology·2023·Department of Animal Pathology, Spain·View original on PubMed →
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Original publication title: Feline osteochondromatosis in a 12-year-old feline leukaemia virus-negative cat.
- Species:
- cat
Plain-English summary
A 12-year-old female Russian Blue cat was brought in with severe joint problems, including swelling and stiffness in her elbows and chest area. X-rays showed abnormal growths in her joints that were causing her bones to fuse together, leading to significant discomfort. Tests ruled out feline leukemia virus as a cause, and genetic testing showed no mutations linked to the condition. Unfortunately, the cat's condition was serious, and treatment options were limited due to the nature of the disease.
People also search for: cat joint problems · Russian Blue cat arthritis · feline osteochondromatosis treatment
Abstract
Feline osteochondromatosis is a spontaneous osteocartilaginous exostosis associated with feline leukaemia virus (FeLV) infection or due to a frameshift variant in the exostosin glycosyltransferase 1 (EXT1) gene. Osteochondromatosis was diagnosed in an indoor-only, 12-year-old, neutered female, Russian Blue cat. Radiographs revealed bilateral calcified proliferations in the elbow, costochondral and sternochondral joints, which distorted the normal skeletal structure. Grossly, the proliferated joints presented with consistent, rounded masses, causing complete ankylosis. The main histopathological finding was an osteocartilaginous proliferation composed of multiple irregular islands of well-differentiated hyaline cartilage surrounded and delimited by osteoid tissue. Immunohistochemistry of the osteochondromas, bone marrow and mediastinal lymph nodes, using a primary anti-FeLV gp70 antibody, and FeLV proviral DNA real-time polymerase chain reaction on bone marrow were negative. Sequencing of exon 6 of the EXT1 gene was performed and nucleotide BLAST analysis demonstrated the absence of a frameshift variant. This study reports the only case of spontaneous feline osteochondromatosis in an animal more than 10 years old.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37597496/