Peer-reviewed veterinary case report
Fibroblast growth factor-2 helps lung blood flow in dogs
By Morino, Shigeyuki et al.·Published in Chest·2005·Nagasaki University School of Medicine, Japan·View original on PubMed →
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Original publication title: Fibroblast growth factor-2 induces recovery of pulmonary blood flow in canine emphysema models.
- Species:
- dog
Plain-English summary
A group of 15 adult beagle dogs with emphysema received a treatment called FGF-2, delivered through a special method that helps it work longer in the lungs. After treatment, the dogs showed improved oxygen levels and better lung function compared to those who received a placebo. The study found that this method of delivering FGF-2 helped restore blood flow in the damaged lungs, leading to noticeable recovery in their breathing.
People also search for: beagle dog emphysema treatment · improving dog lung function · FGF-2 for dog breathing problems
Abstract
STUDY OBJECTIVES: Fibroblast growth factor (FGF)-2 is one of the most powerful angiogenic growth factors to be evaluated as an agent for the promotion of angiogenesis. The aim of this study is to investigate whether intratracheal administration of controlled-release FGF-2 microspheres restores pulmonary function in beagle dogs with emphysema. DESIGN: Randomized, controlled, experimental animal study. SUBJECTS: Eighteen Wister rats and 15 adult beagle dogs. METHODS: In the rat study, we compared the time profiles of the radioactivity remaining after intratracheal injection of 125I-labeled FGF-2, either incorporated with the controlled-release microspheres or as an aqueous solution. In the dog study, elastase-induced emphysema models were developed in 10 animals, classified into the following three groups: control group (n = 5), emphysema model with empty microspheres-treated group (FGF - group, n = 5), and emphysema model with FGF-2 containing microspheres-treated group (FGF + group, n = 5). RESULTS: In the rat study, controlled-release microspheres maintained higher whole-lung FGF-2 concentrations after intratracheal administration. In the dog study, Pa(O2) in the FGF + group was significantly higher than in the FGF - group after treatment. Pulmonary perfusion dynamic MRI revealed significant improvement in the signal intensity of damaged lung with the FGF + group. Linear intercept of the FGF + group was significantly reduced than the FGF - group. CONCLUSION: Results indicate that intratracheal administration of FGF-2 induced an increase in pulmonary blood flow in the damaged lung and led to recovery of pulmonary function. The controlled-release microsphere system increased the effectiveness of FGF-2.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16100187/