Peer-reviewed veterinary case report
Fluralaner plus moxidectin spot-on stops ticks and fleas on cats
By Rohdich, Nadja et al.·Published in Parasites & vectors·2018·MSD Animal Health Innovation GmbH, Germany·View original on PubMed →
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Original publication title: Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats.
- Species:
- cat
Plain-English summary
A study involving 707 cats showed that a single treatment with a spot-on product containing fluralaner and moxidectin (Bravecto Plus) was highly effective against fleas and ticks. Cats treated with this product had over 97% effectiveness in eliminating fleas and ticks after 12 weeks, compared to lower success rates with another common treatment, fipronil. Most cats treated with Bravecto Plus were free of these parasites, and the treatment was found to be safe and well-tolerated. This means that if your cat is dealing with fleas or ticks, Bravecto Plus could be a very effective option.
People also search for: cat flea treatment · cat tick prevention · Bravecto Plus for cats · fipronil vs Bravecto for cats · how to get rid of fleas on cats
Abstract
BACKGROUND: A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) has been developed to provide broad spectrum parasite protection for cats. The effectiveness and safety of this product against ticks and fleas was assessed in a randomized, controlled, 12-week study in client-owned cats in Germany and Spain. METHODS: Eligible households containing at least one cat with at least two fleas and/or two ticks were allocated randomly in a 2:1 ratio to a single treatment with fluralaner plus moxidectin on Day 0, or three 4-weekly treatments with fipronil (Frontline®). Veterinary staff, masked to treatment, completed tick and flea counts on each cat at 14 ± 2 (2 weeks), 28 ± 2 (4 weeks), 56 ± 2 (8 weeks) and 84 ± 2 days (12 weeks) after the initial treatment. RESULTS: In total, 707 cats (257 with ticks) from 332 households (236 with fleas) were included. Ixodes ricinus (78%) and Rhipicephalus sanguineus complex (18%) ticks were the most commonly identified. Tick and flea counts were lower in the fluralaner plus moxidectin group than in the fipronil group throughout the study and the efficacy of fluralaner plus moxidectin exceeded 97 and 98%, respectively. At 12 weeks, 94.1 and 93.3% of cats from the fluralaner plus moxidectin and 92.2 and 60.3% of cats from the fipronil group were free of ticks and fleas, respectively. Fluralaner plus moxidectin was non-inferior to fipronil (P < 0.0001) at all assessments and superior to fipronil at 2 and 8 weeks for the proportion of cats free of ticks (P < 0.0001). Fluralaner plus moxidectin was superior to fipronil for the proportion of both households and cats free of fleas (P < 0.0001). Both products were safe and well tolerated. CONCLUSIONS: A single application of fluralaner plus moxidectin spot-on was well tolerated by cats and highly effective for 12 weeks against ticks and fleas. Fluralaner plus moxidectin was non-inferior to fipronil for the proportion of ectoparasite-free and consistently superior to fipronil in controlling fleas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30454052/