Peer-reviewed veterinary case report
Effectiveness of Procox oral suspension for treating dog intestinal
By Altreuther, Gertraut et al.·Published in Parasitology research·2011·Bayer Animal Health GmbH, Germany·View original on PubMed →
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Original publication title: Field evaluations of the efficacy and safety of Emodepside plus toltrazuril (Procox® oral suspension for dogs) against naturally acquired nematode and Isospora spp. infections in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with intestinal parasite infections, including nematodes and Isospora spp., were treated with a new medication called Procox, which contains emodepside and toltrazuril. After treatment, these dogs showed a complete reduction in parasite eggs in their stool, indicating the medication was very effective. In comparison, other commonly used treatments also worked well, but Procox performed even better in some cases. Importantly, no side effects were reported in any of the dogs during the studies. This suggests that Procox is a safe and effective option for treating these types of infections in dogs.
People also search for: dog intestinal parasites treatment · Procox for dogs · Isospora infection in dogs · nematode treatment for dogs
Abstract
Three controlled, blinded and randomised multicentre field studies evaluated the efficacy and safety of a new formulation containing emodepside plus toltrazuril (Procox® suspension for dogs) against naturally acquired parasite infections in dogs. In two studies dogs positive for gastrointestinal nematodes and/or Isospora spp. were treated with emodepside/toltrazuril suspension (at least 0.45 mg emodepside plus 9 mg toltrazuril per kg body weight) or a reference product containing either milbemycin oxime plus praziquantel (Milbemax®) or sulfadimethoxine (Kokzidiol SD®) at recommended dose rates. The third study investigated efficacy against prepatent natural Isospora spp. infections in comparison to an untreated control group by enrolling Isospora- negative dogs that were at risk to develop a patent infection during the study.No suspected adverse drug reactions were observed in any of the 403 dogs enrolled in the three studies including 234 dogs treated with emodepside/toltrazuril suspension. In dogs treated with emodepside/toltrazuril suspension against nematode infection faecal egg counts were reduced by 100 % (reference product: 99.7 %). Similarly, in the dogs that had been treated against patent Isospora spp. infection, faecal oocyst counts were reduced by 100 % (reference product: 99.0 %). In both studies, statistical analysis demonstrated non-inferiority and even superiority to the reference products (p ≤ 0.009). Dogs treated with emodepside/toltrazuril suspension during suspected prepatent Isospora spp. infection had 98.7 % lower faecal oocyst counts after treatment compared to untreated dogs (p < 0.0001).The studies demonstrated that emodepside/toltrazuril suspension is safe and highly efficacious against nematodes and Isospora spp. under field conditions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21739372/