Peer-reviewed veterinary case report
Rabies DNA vaccine gives dogs long-lasting protection and antibodies
By Bahloul, Chokri et al.·Published in Vaccine·2006·Laboratoire d'Immunopathologie Vaccinologie et Gé·View original on PubMed →
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Original publication title: Field trials of a very potent rabies DNA vaccine which induced long lasting virus neutralizing antibodies and protection in dogs in experimental conditions.
- Species:
- dog
Plain-English summary
A group of dogs received a new rabies DNA vaccine, which was found to be much more effective at creating long-lasting protection against rabies compared to a traditional vaccine. The DNA vaccine was given as a single dose in the ear, while the standard vaccine required one or two doses to achieve similar results. Remarkably, four years later, all dogs that received the DNA vaccine were still fully protected against rabies. This new approach could help improve rabies control in areas where vaccination is crucial, as it may require fewer doses to keep dogs safe.
People also search for: dog rabies vaccine effectiveness · rabies vaccine for dogs · DNA vaccine for rabies in dogs
Abstract
Kinetics of antibody responses and protection against rabies were investigated after injection of a single dose of rabies DNA vaccine and compared to those induced by one or two injections of cell culture-derived vaccine in dogs issued from the common local breed and reared in experimental conditions. Rabies DNA vaccine administered intradermally by a jet injector in the inner face of the ear was by far more efficient in inducing long lasting high titers of virus neutralizing antibodies compared to cell culture vaccine Rabisin administered either subcutaneously or intramuscularly. Four years after vaccine administration of either DNA or cell culture-derived rabies vaccines, full protection against a rabies peripheral challenge was achieved. Vaccine trials targeting dogs living in field conditions in Tunisia further established that rabies DNA-based vaccination induced a stronger induction of virus neutralizing antibodies compared to Rabisin. This report shows for the first time that DNA vaccination could be more efficient under experimental or field conditions in large size mammals than the best commercially available cell culture-derived vaccine. This improvement will hopefully allow a better rabies control in developing countries by using a more efficient vaccination with fewer doses and targeting all categories of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16213633/