Peer-reviewed veterinary case report
Fine mapping of quantitative trait Loci on bovine chromosome 6 affecting calving difficulty.
- Journal:
- Journal of dairy science
- Year:
- 2008
- Authors:
- Olsen, H G et al.
- Affiliation:
- Department of Animal and Aquacultural Sciences
Abstract
Calving difficulty is an economically and ethically important trait for dairy cattle breeding. The aim of the present paper was to refine the position of a previously detected quantitative trait locus (QTL) affecting calving difficulty (direct effect) in Norwegian Red dairy cows. A granddaughter design consisting of 18 elite sire families and a total of 713 sons was genotyped for 154 markers spanning the QTL region, and the trait data were analyzed by using a combined linkage and linkage disequilibrium approach. A highly significant QTL was detected in a 150-kb interval between the markers LAP3_281 and BTA-114677. Additionally, there were some indications of a second QTL between the markers BTA-75776 and BTA-75780 located less than 500 kb apart. Several candidate genes may be identified close to these QTL. Of these, a cluster of genes expected to affect bone and cartilage formation may be of particular interest for follow-up studies.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18946137/