Peer-reviewed veterinary case report
German Hunting Terrier with bladder stones from SLC2A9 gene defect
By Emming, Christin et al.·Published in Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·2024·Stiftung Tierä, Germany·View original on PubMed →
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Original publication title: [First detection of the SLC2A9:p.C188F gene defect in a German Hunting Terrier with ammonium urate urolithiasis].
- Species:
- dog
Plain-English summary
A 1.5-year-old male German Hunting Terrier was brought to the vet with blood in his urine. An ultrasound showed multiple stones in his bladder, and tests revealed he had a condition called ammonium urate urolithiasis, which means he had bladder stones made of a specific type of crystal. After surgery to remove the stones, it was discovered that he had a genetic defect that caused high levels of uric acid in his urine. This case highlights the importance of considering this genetic issue in breeds other than Dalmatians.
People also search for: dog blood in urine · German Hunting Terrier bladder stones · ammonium urate urolithiasis treatment
Abstract
A 1,5-year-old intact male German Hunting Terrier was initially presented 2018 with hematuria. An abdominal ultrasound revealed multiple hyperechogenic structures in the urinary bladder. A urinalysis indicated severe crystalluria (ammonium urate or xanthine). Following cystotomy and urinary calculus analysis, ammonium urate urolithiasis was diagnosed in 2019. The patient was tested homozygous at thevariant, which results in severe hyperuricemia and hyperuricosuria. This case report presents the first incidence of thegene variant being detected in a German Hunting Terrier. Veterinary practitioners are encouraged to consider the possibility of this gene defect presenting in breeds beyond the Dalmatian.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39173651/