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Peer-reviewed veterinary case report

First-line therapy for high-risk people with chronic lymphocytic leukemia: a network meta-analysis.

Year:
2024
Authors:
Miyamoto K et al.
Affiliation:
Department of Health Policy and Informatics · Japan

Abstract

<h4>Objectives</h4>This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective: to assess the benefits and harms of currently recommended regimens as the first-line therapy in high-risk people with chronic lymphocytic leukemia, using network meta-analysis Secondary objectives: to assess whether the benefits and harms of the recommended regimens differ according to sex, Rai stage, or genetic mutation status to estimate the ranking of treatments for overall survival, progression-free survival, objective response rate, complete response rate, minimal residual disease, and serious adverse events to estimate the overall rate of adverse events and serious adverse events.

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Original publication: https://europepmc.org/article/MED/39474946