Peer-reviewed veterinary case report
Drug-resistant E. coli found in dog with uterine infection in Japan
By Harada, Kazuki et al.·Published in Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2024·Tottori University, Japan·View original on PubMed →
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Original publication title: First report of a bla-carrying Escherichia coli sequence type 12 isolated from a dog with pyometra in Japan.
- Species:
- dog
Plain-English summary
A dog in Japan was hospitalized with a serious infection called pyometra, which is an infection of the uterus. Tests on the pus from the dog's uterus revealed a type of E. coli bacteria that was resistant to many common antibiotics. Fortunately, the dog was successfully treated with doxycycline and orbifloxacin, two antibiotics that worked against the infection. This case highlights the importance of monitoring antibiotic resistance in pets, as it can affect both animal and human health.
People also search for: dog pyometra treatment · antibiotic resistance in dogs · E. coli infection in pets
Abstract
Carbapenemase-producing Enterobacterales (CPE) are a serious concern in human clinical settings. Companion animal-origin CPE have been only rarely identified in several countries, but they have not yet been identified in Japan. In this study, we present the first case of a canine infected with CPE in Japan. The patient was hospitalized due to pyometra. The pus discharged from the patient's uterus was subjected to bacteriological analysis. As a result, E. coli was identified in the pus and exhibited resistance to piperacillin, amoxicillin-clavulanic acid, cefazolin, ceftazidime, cefepime, meropenem, amikacin, and sulfamethoxazole-trimethoprim and susceptibility to aztreonam, minocycline, and levofloxacin. Results of the sodium mercaptoacetic acid double-disk synergy test showed that the E. coli isolate was positive for metallo-β-lactamases. Next-generation sequencing identified the blagene, which was located in the IncFII-type plasmid together with bla, rmtB, aadA2, bleMBL, sul1, qacE, and dfrA12. The case was treated successfully with doxycycline and orbifloxacin. Our finding emphasizes that close attention should be paid to the significance of CPE harboring multidrug-resistance plasmid in companion animals, based on the perspective of One Health approach in Japan as well as in other countries.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38369122/