Peer-reviewed veterinary case report
First report of macrolide resistance gene erm(T) harbored by a novel small plasmid from Erysipelothrix rhusiopathiae.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2015
- Authors:
- Xu, Chang-Wen et al.
- Affiliation:
- College of Life Sciences · China
Abstract
The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G+C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fold the MICs of clindamycin and erythromycin for E. rhusiopathiae. The fitness cost of pER29 could be responsible for the low frequency of erm(T) in E. rhusiopathiae.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25666150/