Peer-reviewed veterinary case report
Polycystic kidney disease found in Persian cats in Serbia
By Vucicevic, Milos et al.·Published in Veterinaria italiana·2016·University of Belgrade·View original on PubMed →
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Original publication title: First report of Polycystic kidney disease occurrence in Persian cats in Serbia.
- Species:
- cat
Plain-English summary
A group of Persian cats in Serbia was tested for polycystic kidney disease (PKD), an inherited condition that can lead to kidney problems. Researchers found that nearly half of the cats tested positive for PKD using genetic testing, while ultrasound only detected about 19% of cases. This means that genetic testing is a more reliable way to diagnose PKD early, even in very young kittens. All the cats had normal blood and biochemical results, indicating that they were otherwise healthy despite the presence of PKD.
People also search for: Persian cat kidney disease symptoms · PKD genetic testing for cats · ultrasound vs genetic testing for cat kidney disease
Abstract
Polycystic kidney disease (PKD) is an inherited autosomal disorder in cats, mostly diagnosed in Persian cats. Renal cysts can be diagnosed by ultrasound, but cats must be at least 16 weeks old. The goals of this study were to assess the occurrence of PKD in Serbia using a randomly selected group of Persian cats, to compare the diagnostic efficacy of ultrasound and genetic tests, and to measure haematological and selected biochemical parameters. We examined 70 cats of Persian breed, between 4 months and 8 years of age. Complete blood count and selected biochemical parameters were measured, renal ultrasound was performed. Swabs of the oral cavity were obtained for genetic testing. Percentage of PKD positive cats identified by genetic testing was 48.6%, whilst only 18.6% were detected through ultrasound. Animals that were polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) positive and ultrasound negative ranged from 4 months to 3.5 years. All haematological and biochemical parameters were within the the normal range values in all examined cats. Genetic methods proved to be the most effective for reliable and early diagnosis of PKD in Persian cats. DNA analysis can be used right after birth, and excludes the need for other diagnostic procedures, such as ultrasound.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27033530/