Peer-reviewed veterinary case report
Testing how dogs with food allergy react to food allergens using
By Fujimura, Masato et al.·Published in The Journal of veterinary medical science·2011·Fujimura Animal Hospital, Japan·View original on PubMed →
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Original publication title: Flow cytometric analysis of lymphocyte proliferative responses to food allergens in dogs with food allergy.
- Species:
- dog
Plain-English summary
A group of dogs with food allergies were tested to see how their immune systems reacted to certain food allergens. Thirteen dogs showed signs of food allergies, and two different allergy tests were used to identify their reactions. After following an elimination diet for 1.5 to 5 months, most of the dogs had a significant decrease in their allergic reactions, especially in the lymphocyte proliferation test, which measures how immune cells respond to allergens. This suggests that food allergies in dogs can be managed effectively with dietary changes.
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Abstract
Two different allergy tests, antigen-specific immunoglobulin E quantification (IgE test) and flow cytometric analysis of antigen-specific proliferation of peripheral lymphocytes (lymphocyte proliferation test), were performed to examine differences in allergic reactions to food allergens in dogs with food allergy (FA). Thirteen dogs were diagnosed as FA based on clinical findings and elimination diet trials. Seven dogs clinically diagnosed with canine atopic dermatitis (CAD) were used as a disease control group, and 5 healthy dogs were used as a negative control group. In the FA group, 19 and 33 allergen reactions were identified using the serum IgE test and the lymphocyte proliferation test, respectively. Likewise, in the CAD group, 12 and 6 allergen reactions and in the healthy dogs 3 and 0 allergen reactions were identified by each test, respectively. A significant difference was found between FA and healthy dogs in terms of positive allergen detection by the lymphocyte proliferation test, suggesting that the test can be useful to differentiate FA from healthy dogs but not from CAD. Both tests were repeated in 6 of the dogs with FA after a 1.5- to 5-month elimination diet trial. The IgE concentrations in 9 of 11 of the positive reactions decreased by 20-80%, whereas all the positive reactions in the lymphocyte proliferation test decreased to nearly zero (P<0.05), suggesting that lymphocytes against food allergens may be involved in the pathogenesis of canine FA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21673480/