Peer-reviewed veterinary case report
New gel treatment reduces tendon adhesions after repair surgery
By Smith PA et al.·2026·. TYBR Health·View original on Europe PMC →
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Original publication title: Flowable Extracellular Matrix Hydrogel to Prevent Adhesion Formation Following Flexor Tendon Repair: A Preclinical Study.
- Species:
- rabbit
Plain-English summary
In a study using rabbits, researchers tested a new gel and mesh made from a special type of material called extracellular matrix (ECM) to see if they could help prevent scar tissue from forming after surgery on flexor tendons, which are important for movement. They found that the gel and mesh helped improve the range of motion in the tendons and reduced the amount of scar tissue compared to a control group that didn't receive the treatment. The best results came from the gel that was mixed in a specific way, showing less inflammation and better movement. Importantly, the treatments did not affect the strength of the tendons, meaning they were safe to use. Overall, the study suggests that this new gel and mesh could be effective in reducing complications after tendon surgery.
Abstract
<h4>Background</h4>Adhesion formation following flexor tendon repair remains a significant clinical challenge, often necessitating reoperation and leading to suboptimal outcomes. Current adhesion barrier technologies have limited efficacy and usability.<h4>Methods</h4>A flowable extracellular matrix (ECM) hydrogel and ECM mesh were evaluated in a preclinical rabbit model of flexor tendon repair. Range of motion (ROM), adhesion scoring, and rupture strength were measured. Safety and overapplication effects were assessed in cadaveric tendon models. Histologic analysis evaluated inflammation.<h4>Results</h4>The ECM hydrogel and mesh reduced adhesions and improved ROM compared to saline controls. ROM in treated tendons ranged from 70.4°±17.7° (3:1 Gel) to 69.8°±8.3° (1:1 Gel), significantly higher than controls (50.7°±17.7°; p<0.05). Adhesion scores improved across treated groups, with 1:1 Gel achieving the best results (5.2±1.8 vs. control 8.0±1.5; p<0.05). Histology suggested reduced sustained inflammation in treated groups. No impact on rupture strength was observed, confirming mechanical safety.<h4>Conclusions</h4>Flowable ECM hydrogel and ECM mesh significantly reduce adhesions and preserve tendon mechanics after flexor tendon repair. The hydrogel's flowable form offers superior ease of application, addressing unmet clinical needs.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41811181