Peer-reviewed veterinary case report
Fluorescein sodium helps guide brain tumor surgery in 22 dogs
By Nakano, Yukiko et al.·Published in Veterinary surgery : VS·2018·The Animal Medical Center of Gifu University, Japan·View original on PubMed →
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Original publication title: Fluorescein sodium-guided resection of intracranial lesions in 22 dogs.
- Species:
- dog
Plain-English summary
A group of 22 dogs with suspected brain tumors underwent surgery where a special dye (fluorescein sodium) was used to help the veterinarian see the tumors better. While two dogs experienced some vomiting after the dye was given, the procedure was generally safe. The dye helped identify the tumors accurately, which could improve the chances of successful removal. This technique may help veterinarians better treat dogs with brain tumors in the future.
People also search for: dog brain tumor surgery · fluorescein sodium for dogs · dog vomiting after surgery
Abstract
OBJECTIVE: To evaluate the safety of an intraoperative fluorescein sodium (FS) injection and elucidate the relationships between the MRI findings, pathological diagnoses, and intraoperative staining characteristics of intracranial lesions in 22 dogs. STUDY DESIGN: Prospective case series. ANIMALS: Twenty-two dogs with intracranial lesions. METHODS: FS was intravenously administered to 22 dogs undergoing craniotomy for suspected intracranial tumors to evaluate perioperative and postoperative adverse effects. The intensities and patterns of gadolinium (Gd) enhancement on preoperative magnetic resonance imaging and intraoperative FS staining were graded, and their relationship was evaluated. Intraoperative FS staining characteristics and pathological diagnoses were compared. RESULTS: The only adverse effect noted was repetitive vomiting in 2 dogs. The intensities and patterns between preoperative Gd enhancement and intraoperative FS staining appeared to agree. High-grade glioma and histiocytic sarcoma had more intense FS staining. Lesions with strong Gd enhancement, including meningiomas and choroid plexus tumors, also had intense FS staining. CONCLUSION: The intraoperative use of FS is a simple and safe technique to guide the resection of intracranial lesions in dogs. The findings on Gd enhancement, FS staining, and histopathology appeared to agree but require validation in a larger set of cases. CLINICAL SIGNIFICANCE: The intraoperative use of FS may improve the prognosis of dogs with brain tumors by guiding the resection of lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29247539/