Peer-reviewed veterinary case report
New PAD-S31 light treatment for skin tumors in dogs and a cat
By Tanabe, S et al.·Published in Veterinary journal (London, England : 1997)·2004·Department of Veterinary Clinical Science, Japan·View original on PubMed →
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Original publication title: Fluorescence detection of a new photosensitizer, PAD-S31, in tumour tissues and its use as a photodynamic treatment for skin tumours in dogs and a cat: a preliminary report.
Plain-English summary
A dog and a cat with skin tumors were treated with a new photosensitizer called PAD-S31, which helps make tumors more sensitive to light therapy. After receiving the treatment, both pets underwent a special light therapy that targeted their tumors. The results were promising, as the tumors in both dogs and the cat completely disappeared after the treatment. This suggests that PAD-S31 could be an effective option for treating skin tumors in pets.
People also search for: dog skin tumor treatment · cat skin cancer therapy · PAD-S31 photosensitizer for pets · photodynamic therapy for dogs · skin tumors in cats
Abstract
We describe here the detection by fluorescence of a new photosensitizer, PAD-S31, in tumours in dogs and cats and the effect of photodynamic therapy (PDT) by using PAD-S31 for skin tumours in two dogs and one cat. PAD-S31 is a hydrophilic photosensitizer that has two peaks at absorption wavelengths 406 and 665 nm in distilled water. In a preliminary experiment in mice transplanted with SCCVII and colon 26, PAD-S31 was retained in tumour tissues rather than in other organs. The tumours resected from dogs and cats after intravenous administration of PAD-S31 at a dose of 15 mg/kg emitted strong red fluorescence under light illumination of 402 nm wavelength. Animals given PAD-S31 showed no cutaneous photosensitivity under room light illumination. Irradiation at laser light 670 nm wavelength (fluence rate 150 mW/cm2 and total light dosage 150 J/cm2) on cutaneous mast cell tumours in dogs ( n=2 ) and a cutaneous basal cell tumour in a cat induced complete remission. These results suggest PAD-S31 could be a promising photosensitizer for use in a small animal veterinary practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15080878/