Peer-reviewed veterinary case report
Enrofloxacin urine levels in dogs exceed resistance prevention
By Daniels, J B et al.Ā·Published in Journal of veterinary pharmacology and therapeuticsĀ·2014Ā·Department of Veterinary Clinical Sciences, United StatesĀ·View original on PubMed ā
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Original publication title: Fluoroquinolone levels in healthy dog urine following a 20-mg/kg oral dose of enrofloxacin exceed mutant prevention concentration targets against Escherichia coli isolated from canine urinary tract infections.
- Species:
- dog
Plain-English summary
A group of six healthy dogs was given a 3-day course of enrofloxacin, a common antibiotic, to treat uncomplicated urinary tract infections (UTIs). The dose was 20 mg/kg once a day, and it was found that the levels of the antibiotic in their urine were much higher than what is needed to prevent resistant bacteria from developing. This means that using this treatment is unlikely to lead to antibiotic-resistant infections in the bladder. However, more research is needed to see how effective this treatment is in other parts of the body where the antibiotic might not reach as high levels.
People also search for: dog urinary tract infection treatment Ā· enrofloxacin for dog UTI Ā· antibiotic resistance in dogs
Abstract
A 3-day course of oral enrofloxacin is effective for treating uncomplicated urinary tract infection (UTI) in dogs when administered 20 mg/kg Q24H. However, emergence of fluoroquinolone-resistant mutants of uropathogens is a concern. Urine concentrations of enrofloxacin and ciprofloxacin were measured in six healthy dogs following dose of enrofloxacin 20 mg/kg. Mutant prevention concentrations of Escherichia coli isolated from canine UTI were also determined against ciprofloxacin. Urine AUC(24)/MPC ratios considering ciprofloxacin concentrations ranged 3819-7767, indicating that selection of resistant E. coli mutants in dogs with uncomplicated UTIs is unlikely in the bladder given that an AUC(24)/MPC = 39 is considered to be protective against mutant selection for ciprofloxacin. However, additional studies are required to evaluate the effects of this enrofloxacin treatment protocol on bacteria that colonize anatomic sites where fluoroquinolones achieve lower concentrations compared to the urinary bladder.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23859001/