Peer-reviewed veterinary case report
Anxiety treatment in dogs using fluoxetine and clorazepate
By Pineda, S et al.·Published in Veterinary journal (London, England : 1997)·2014·Universidad Complutense de Madrid, Spain·View original on PubMed →
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Original publication title: Fluoxetine combined with clorazepate dipotassium and behaviour modification for treatment of anxiety-related disorders in dogs.
- Species:
- dog
Plain-English summary
A group of 40 dogs with anxiety disorders, including some that showed aggression, were treated with a combination of fluoxetine and clorazepate dipotassium, along with a behavior modification plan. After the treatment, 25 out of 36 dogs showed improvement in their anxiety symptoms. The treatment involved giving the dogs both medications daily for several weeks, and owners who followed the behavior plan closely saw better results. This approach helped many dogs feel more relaxed and less anxious over time.
People also search for: dog anxiety treatment · fluoxetine for dogs · clorazepate dipotassium for dog anxiety · behavior modification for anxious dogs
Abstract
The effectiveness of clorazepate dipotassium combined with fluoxetine and a behaviour modification programme for the treatment of anxiety disorders in dogs was investigated. Forty dogs with anxiety disorders were initially enrolled and 36 dogs completed the trial. Dogs were classified into two behavioural categories (anxious dogs with aggression and anxious dogs without aggression) according to their presenting complaints, and were also subdivided into males, females, juveniles and adults. The dog owners were provided with a behaviour modification plan for their dogs to be commenced in the first week of therapy. Clorazepate dipotassium was administered PO at 1.0 mg/kg every 24 h for 4 weeks, and fluoxetine was administered PO at 1.0 mg/kg every 24 h for 10 weeks. Therapy with both drugs was initiated simultaneously. Improvement was reported in 25/36 dogs. Significant differences in treatment effects were observed between anxious dogs with aggression and anxious dogs without aggression (P<0.05). Positive correlations between owner compliance with the treatment plan and reported improvement achieved during three periods of study were also noted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24439470/