Peer-reviewed veterinary case report
Fluoxetine did not reduce itching in dogs with atopic dermatitis
By Fujimura, M. et al.·Published in Polish Journal of Veterinary Sciences·2014·View original on Crossref →
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Original publication title: Fluoxetine (SSRI) treatment of canine atopic dermatitis: a randomized, double-blind, placebo-controlled, crossover trial
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy condition) was treated with fluoxetine, a medication typically used for anxiety and depression, to see if it would help reduce their itching. After a two-month trial, the results showed that fluoxetine did not significantly improve the dogs' itching or skin condition compared to a placebo. In fact, two dogs dropped out of the study due to depression. Overall, fluoxetine was not effective for treating itching in dogs with atopic dermatitis, indicating that more research is needed to find better treatments.
People also search for: dog itching treatment · fluoxetine for dog allergies · canine atopic dermatitis medication
Abstract
Abstract This study investigated effects of a fluoxetine (selective serotonin reuptake inhibitors; SSRI, 1 mg/kg) on pruritus in canine atopic dermatitis (CAD). After 4-weeks of base-line observation, 8 dogs with CAD entered a 2-months randomized, double-blind, placebo-controlled, crossover trial comparing fluoxetine with placebo. Clinical efficacy was evaluated using a Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) and Pruritus Visual Analog Scale (PVAS). Six dogs completed the study [two out of eight dogs (both of them were Shiba Inu) dropped out from the study due to a depression]. CADESI-03 and PVAS between fluoxetine and placebo showed no significant difference statistically (P>0.05 and P>0.05 respectively). Fluoxetine showed no efficacy on pruritus in CAD. Further researches are needed for the treatment on pruritus of CAD
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Search related cases →Original publication on Crossref: https://doi.org/10.2478/pjvs-2014-0053