Peer-reviewed veterinary case report
Dog with kidney damage linked to infectious canine hepatitis virus
By Hervás, J et al.·Published in Veterinary immunology and immunopathology·1997·Dpto. Anatomí, Spain·View original on PubMed →
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Original publication title: Focal mesangial-sclerosing glomerulonephritis and acute-spontaneous infectious canine hepatitis: structural, immunohistochemical and subcellular studies.
- Species:
- dog
Plain-English summary
A dog with acute infectious canine hepatitis (ICH) showed signs of kidney problems, specifically changes in the glomeruli, which are tiny filters in the kidneys. The dog's condition included swelling in the kidney's filtering units and the presence of viral particles linked to the hepatitis. Tests revealed that the virus was actively replicating in the kidney cells. Unfortunately, the abstract does not provide information on treatment or the dog's recovery.
People also search for: dog kidney problems · infectious canine hepatitis symptoms · dog glomerulonephritis treatment
Abstract
The glomerular alterations observed in a dog with acute spontaneous infectious canine hepatitis (ICH) are described. Histologic changes of the glomeruli were enlargement of the mesangium with presence of intranuclear inclusion bodies and without proliferation of mesangial cells. Electron microscopy revealed adenovirus replication sites in glomerular mesangial cells and in endothelial cells of glomerular capillaries, as well as a focal mesangial-sclerosing glomerulonephritis associated with electron dense deposits which were closely related with extracellular ICH viral particles and immunohistochemically reactive for immunoglobulin (Ig) G, IgA, IgM and C3c complement components.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9239835/