Peer-reviewed veterinary case report
Changes in urine protein levels during obstructive feline idiopathic
By Treutlein, G et al.·Published in Veterinary journal (London, England : 1997)·2013·Clinic of Small Animal Medicine, Germany·View original on PubMed →
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Original publication title: Follow-up protein profiles in urine samples during the course of obstructive feline idiopathic cystitis.
- Species:
- cat
Plain-English summary
A group of cats with a history of obstructive feline idiopathic cystitis (FIC) had their urine tested to see how certain proteins changed over time. Initially, these cats showed higher levels of total protein, fibronectin, and thioredoxin in their urine compared to healthy cats. After three months, the total protein levels decreased significantly, indicating some improvement. However, the levels of fibronectin and thioredoxin remained high, suggesting ongoing issues in their urinary bladders. This study highlights the importance of monitoring these protein levels in cats with FIC to understand their condition better.
People also search for: cat urinary problems · feline idiopathic cystitis treatment · cat bladder health · why is my cat peeing frequently · cat urine protein levels
Abstract
Feline idiopathic cystitis (FIC) is a common lower urinary tract disorder in cats, which often recurs. Published reports document increased urine fibronectin and thioredoxin concentrations in cats with FIC compared with healthy control cats. Therefore, these proteins might be of interest in the pathophysiology of FIC. The purpose of the present study was to evaluate variations in these urine proteins throughout the course of FIC by assessing their concentrations in urine specimens from cats with a history of obstructive FIC. Urine total protein (TP) was measured using the Bradford assay, while urine fibronectin and thioredoxin concentrations were determined by Western blot analysis. Urine TP was significantly higher in cats with obstructive FIC at presentation (day 0) than in healthy control cats (P<0.01). There were significant decreases in urine TP in cats with obstructive FIC after 3 months (P<0.01). Significantly higher urine fibronectin (P<0.01) and thioredoxin (P<0.05) concentrations were demonstrated in cats with FIC at day 0 compared to control cats, but there was no significant change over time (P>0.05). Increased concentrations of these proteins over time might reflect ongoing structural and pathological alterations to functional processes in the urinary bladders of cats with obstructive FIC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24257070/