FORMATION OF ARTIFICIAL BURNS IN WISTAR RATS TO EVALUATE THE EFFECTS OF DIFFERENT DRUGS.

Abstract

Burns are a common problem faced by mankind, which in turn affects function and quality of life. Over the centuries, many anti-burn drugs have been developed. In this article the effect of different preparations: Agrosulfan-anti-burn preparation, Shostakovsky's Balsam-anti-burn preparation, Alfazox-esophagoprotector, on artificially formed burns with the help of electrocoagulator on Wistar rats is considered. The rats were kept in standard vivarium conditions in cages under natural light regime and on normal diet with free access to water and food. Comparison of preparations was carried out, the indication of which is treatment of burns. But in comparison with other preparations «Alfazox» is an esophagoprotector, on the basis of its properties (promotes healing of gastric mucosa erosions) and composition (Chondroitin sulfate + hyaluronic acid + poloxamer 407), this preparation can be prescribed for burns off-label. By means of daily measurement of the burn surface area and estimation of tissue repair rate. preparations showed the following results: Agrosulfan - complete epithelization of the wound occurred on the 11th day, showed the best result, «Alfazox» - 13 days, belonging to esophagoprotectors, in contrast to the control group (16 days), which makes it possible to prescribe it off-label. The period of complete epithelialisation of Shostakovsky's Balsam was 14 days. The terms of the control group were 16 days.