Peer-reviewed veterinary case report
Four new genes linked to longer life in Cane corso dogs
By Korec, Evžen et al.·Published in BMC veterinary research·2022·Zoologická·View original on PubMed →
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Original publication title: Four novel genes associated with longevity found in Cane corso purebred dogs.
- Species:
- dog
Plain-English summary
A genetic study found four specific genes linked to longer lifespans in Cane Corso dogs. Researchers identified variations in these genes—TDRP, MC2R, FBXO25, and FBXL21—that were more common in dogs that lived longer. Notably, a change in the FBXL21 gene was observed, where a certain protein building block was different in long-lived dogs compared to others. This discovery could help understand what contributes to a longer life in these dogs, potentially guiding future breeding and care practices.
People also search for: Cane Corso lifespan · dog longevity genes · how to help my dog live longer · Cane Corso health issues · genetic testing for dogs
Abstract
BACKGROUND: Longevity-related genes have been found in several animal species as well as in humans. The goal of this study was to perform genetic analysis of long-lived Cane corso dogs with the aim to find genes that are associated with longevity. RESULTS: SNPs with particular nucleotides were significantly overrepresented in long-lived dogs in four genes, TDRP, MC2R, FBXO25 and FBXL21. In FBXL21, the longevity-associated SNP localises to the exon. In the FBXL21 protein, tryptophan in long-lived dogs replaced arginine present in reference dogs. CONCLUSIONS: Four SNPs associated with longevity in dogs were identified using GWAS and validated by DNA sequencing. We conclude that genes TDRP, MC2R, FBXO25 and FBXL21 are associated with longevity in Cane corso dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35590325/