Peer-reviewed veterinary case report
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.
- Journal:
- Nature neuroscience
- Year:
- 2010
- Authors:
- Brown, Maile R et al.
- Affiliation:
- Department of Pharmacology · United States
- Species:
- rodent
Abstract
In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/20512134/