Peer-reviewed veterinary case report
From theory to therapy: a One Health approach guides current and future acid suppressant use in veterinary medicine.
- Journal:
- Journal of the American Veterinary Medical Association
- Year:
- 2024
- Authors:
- Grady, Kylie et al.
- Affiliation:
- College of Veterinary Medicine
- Species:
- cat
Plain-English summary
Acid-suppressant drugs (ASDs) are important medications used to treat problems like acid reflux and stomach ulcers in pets, just like they are in people. This article discusses how these drugs work in both humans and small animals, pointing out the differences between species and what we still need to learn, especially about cats. It also raises concerns about the overuse of these medications and their potential side effects in dogs and cats. Overall, the article aims to improve our understanding of how these drugs can be used safely and effectively in veterinary medicine. The findings suggest that while ASDs are helpful, more research is needed to ensure they are used appropriately in pets.
Abstract
Acid-suppressant drugs (ASDs) have revolutionized the treatment of acid-related disorders such as gastroesophageal reflux and gastrointestinal ulceration in both human and veterinary species. However, continued advancement in this field is dependent on a shared understanding of both human and veterinary research as well as an appreciation for species similarities and differences. In this Currents in One Health article, we will compare the efficacy of and indications for ASDs in humans and small animals, noting species differences and knowledge gaps when applicable. We will also highlight areas where further research is needed, specifically emphasizing the need for more feline research and a better understanding of which diseases may benefit from gastroprotection. Finally, given the rising overuse of ASDs in both human and veterinary medicine, we will explore the known adverse effects of these drugs in dogs and cats. This article is focused on our current understanding of these drugs in veterinary medicine and their clinical implications. The companion Currents in One Health article by Gould et al, AJVR, October 2024, will explore the future of ASD research and use by evaluating these drugs' pH-independent effects in humans and rodent models.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39168146/