Peer-reviewed veterinary case report
Fucosidosis causing behavior changes in American English Springer
By Smith, M O et al.·Published in Journal of the American Veterinary Medical Association·1996·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Fucosidosis in a family of American-bred English Springer Spaniels.
- Species:
- dog
Plain-English summary
A family of American-bred English Springer Spaniels was found to have fucosidosis, a genetic disorder that affects the brain and can cause changes in behavior. This condition was previously unreported in American dogs, and it can be mistaken for other behavior or neurological issues. The disease is inherited, meaning that carrier dogs appear healthy but can pass the gene on to their puppies. If you notice unusual behavior changes in your dog, it’s important to consult your veterinarian for proper diagnosis and management.
People also search for: English Springer Spaniel behavior changes · dog neurological problems · fucosidosis in dogs · inherited diseases in dogs
Abstract
Fucosidosis was detected in a family of English Springer Spaniels in the United States. To our knowledge, these are the first reported cases of this disease in American-bred dogs. Affected and carrier status of dogs were determined by measuring the activity of the enzyme alpha-L-fucosidase in plasma and in leukocytes. Fucosidosis results in neurologic signs, particularly changes in behavior, in adolescent and adult dogs. Late onset of signs may result in misdiagnosis as a primary behavior problem or acquired neurologic disease. Fucosidosis is inherited in an autosomal recessive manner, and carrier dogs are clinically normal. Thus, the abnormal gene can become widespread in a population before homozygous-affected dogs are produced.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8960193/