Peer-reviewed veterinary case report
Fully virulent Bacillus anthracis does not require the immunodominant protein BclA for pathogenesis.
- Journal:
- Infection and immunity
- Year:
- 2007
- Authors:
- Bozue, J et al.
- Affiliation:
- U.S. Army Medical Research Institute of Infectious Diseases · United States
Abstract
The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17074844/