Peer-reviewed veterinary case report
Dog fecal incontinence treated with muscle cell and bead injections
By Oh, Heung-Kwon et al.·Published in Diseases of the colon and rectum·2015·1 Department of Surgery, South Korea·View original on PubMed →
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Original publication title: Functional and histological evidence for the targeted therapy using biocompatible polycaprolactone beads and autologous myoblasts in a dog model of fecal incontinence.
- Species:
- dog
Plain-English summary
A group of dogs with fecal incontinence, caused by surgery that damaged their anal sphincter, received injections of special beads containing their own muscle cells to help improve their condition. After three months, the dogs that received the treatment showed better anal sphincter pressure compared to those that did not receive the injections. This suggests that the treatment could help dogs with similar issues regain better control. While this study was done in a controlled setting, it points to a potential new option for managing fecal incontinence in dogs.
People also search for: dog fecal incontinence treatment · anal sphincter surgery dog · muscle cell injection for dogs
Abstract
BACKGROUND: Injection of bulking agents into the anal canal is limited by several factors, including biological resorption, particle migration, and ongoing degradation of the injected bulking agent. OBJECTIVE: We investigated whether an injection of polycaprolactone beads containing autologous myoblasts could improve sphincter function in a dog model of fecal incontinence. DESIGN: The control sham surgery group underwent skin incision around the anal sphincter (n = 5). Fecal incontinence was induced by resecting 25% of the posterior internal/external anal sphincter in another 10 dogs. After 1 month of sphincter injury, dogs were then treated with (n = 5) or without (n = 5) polycaprolactone beads containing PKH-26-labeled autologous myoblasts. SETTING: This study was conducted at the department of surgery in collaboration with the department of advanced materials. OUTCOME MEASURES: Three months after injection treatment, the resting and contractile pressure differences of the anal sphincter were compared, and histopathological studies were performed. RESULTS: The anal pressures in untreated dogs were significantly lower than those in the sham surgery group (p < 0.05). The resting and contractile pressure differences were higher in treated dogs than in untreated dogs (resting pressure difference: 0.7 ± 0.5 vs -0.6 ± 0.8 mmHg; coefficient of the difference in recovery rate, 0.38; 95% CI, 0.15-0.61, p = 0.001; contractile pressure difference: 1.1 ± 4.2 vs -3.9 ± 2.6 mmHg; coefficient, 1.63; 95% CI, 0.55-2.71, p = 0.003). Immunofluorescent staining confirmed that the myoblasts had differentiated and synthesized myosin heavy chain, as observed in vitro. LIMITATIONS: This study was limited by the lack of comparison of injecting beads containing autologous myoblasts with injecting myoblasts alone. CONCLUSION: This study shows that an injection of polycaprolactone beads containing autologous myoblasts may improve anal sphincter function in an animal model of fecal incontinence.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25850839/