Peer-reviewed veterinary case report
Eye pressure and vision changes in dogs with inherited glaucoma
By Grozdanic, Sinisa D et al.·Published in Investigative ophthalmology & visual science·2010·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma.
- Species:
- dog
Plain-English summary
A group of dogs with hereditary primary angle-closure glaucoma showed increasing eye pressure as they aged, starting from 14 mm Hg at 8 months and reaching 36 mm Hg by 30 months. This condition can lead to serious eye problems, including loss of vision due to damage to the optic nerve and retinal cells. Although some tests showed normal retinal function, others indicated significant issues in the dogs with glaucoma. Unfortunately, there is no specific treatment mentioned that can reverse the damage caused by this condition, so regular veterinary check-ups are crucial for managing eye health in affected dogs.
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Abstract
PURPOSE: To characterize functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. METHODS: Intraocular pressure (IOP) was evaluated with tonometry in a colony of glaucomatous dogs at 8, 15, 18, 20, and 30 months of age. Retinal function was evaluated using electroretinography (scotopic, photopic, and pattern). Examination of anterior segment structures was performed using gonioscopy and high-frequency ultrasonography (HFU). RESULTS: A gradual rise in IOP was observed with an increase in age: 8 months, 14 mm Hg (median value); 15 months, 15.5 mm Hg; 18 months, 17.5 mm Hg; 20 months, 24 mm Hg; 30 months, 36 mm Hg. Provocative testing with mydriatic agents (tropicamide and atropine 1%) caused significant increases in IOP (35% and 50%, respectively). HFU analysis showed complete collapse of iridocorneal angles by 20 months of age. Scotopic and photopic ERG analysis did not reveal significant deficits, but pattern ERG analysis showed significantly reduced amplitudes in glaucomatous dogs (glaucoma, 3.5 +/- 0.4 muV; control, 6.2 +/- 0.3 muV; P = 0.004; Student's t-test). Histologic analysis revealed collapse of the iridocorneal angle, posterior bowing of the lamina cribrosa, swelling and loss of large retinal ganglion cells, increased glial reactivity, and increased thickening of the lamina cribrosa. CONCLUSIONS: Canine hereditary angle-closure glaucoma is characterized by a progressive increase in intraocular pressure, loss of optic nerve function, and retinal ganglion cell loss.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19661222/