Peer-reviewed veterinary case report
Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats.
- Journal:
- Epilepsy research
- Year:
- 2005
- Authors:
- Stief, Frank et al.
- Affiliation:
- Neurowissenschaftliches Forschungszentrum der Charité · Germany
- Species:
- rodent
Abstract
Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16154723/